Prebiotics nourish and help the growth of diverse friendly bacteria and support the health of our digestive system. Prebiotic foods act as a carbon source for primary and secondary fermentation pathways in the colon.
Characteristics of Prebiotics
Prebiotics have five important characteristics as:
- Not digested by upper gastrointestinal (GI) tract.
- Reach large colon and fermented by certain microbiota.
- Produce helpful metabolites, reduce colonic pH, and reduce the production of harmful nitrous compounds.
- Have a good effect of GI disorders and other body diseases.
- Not affected by food processing.
Health benefits of Prebiotics
Prebiotics are essentially the food for our gut bacteria. They support both the quality, measured in terms of microbiome diversity or gut bacteria profile and the numbers of the gut bacteria.
Prebiotics are categorized based on their structure and how they interact with our digestive system. Learn here on the categorization.
It is important to consume a variety of prebiotic foods in your diet on regular basis, as different prebiotic foods will support different gut bacteria. A variety in your diet will support the diversity of your gut biome.
Prebiotics support the growth of microbiota
Lactobacilli have been shown to reduce mucosal inflammation in the GI tract. Also, Lactobacilli play a role in helping digest lactose for lactose-intolerant individuals, relief constipation, improve irritable bowel syndrome (IBS) symptoms, and potentially help to prevent traveler’s diarrhea.
Bifidobacteriareside occurs naturally in the GI tract of healthy human adults and have a strong affinity to ferment oligosaccharides. Also, Bifidobacteriareside is negatively associated with obesity and weight gain. A decrease in Bifidobacteriareside occurs with higher IBS inflammations.
Formation of Beneficial Metabolites
Production of short chain fatty acids (SCFAs) as acetate, propionate and butyrate is resulted from fermentation of Prebiotics.
Acetate is an important metabolizable energy source for muscles. Propionate and butyrate are negatively associated with ulcerative colitis.
The fermentation of inulin-type fructans produces hippurate. Hippurate is a microbial mammalian co-metabolite which is found to be less in obese and diabetic patients.
Prebiotics increase Mineral Absorption
Studies show the effect of acid fermentation from Prebiotics by bacteria. This results in enhancing the absorption of calcium from small intestine. Calcium is very important mineral for normal bone growth and prevention of osteoporosis.
Clinical studies conducted to show that: inulin, fructooligosaccharides, galactooligosaccharides, and lactulose can increase calcium uptake from intestine.
Decrease Protein fermentation
Fermentation of protein either from undigestible or endogenous sources, in the absence of carbohydrates is very harmful. This is due to the formation of harmful metabolites as: ammonia and sulfides, indole and phenol compounds.
The fermentation of Prebiotics is beneficial rather than protein fermentation. Studies show that upon taking lactulose (15 gram per day or 2*10 gram per day), it decreases fecal phenol and indole, urinary ammonia , and urinary p-cresol.
Inulin (3*5 gram per day) is found to reduce fecal and urinary ammonia.
Prevent the growth of Pathogenic Bacteria
Prebiotics show to prevent the growth of pathogenic bacteria as E.coli, Salmonella species and Campylobacter species.
A good example for Prebiotics action against pathogenic bacteria is acute diarrhea which is morbid in children. Administration of oral rehydration solution (ORS) alone is not capable to reduce duration and severity of diarrhea.
Studies conducted to evaluate the efficacy of zinc and Prebiotics (FOS and XOS) fortified oral rehydration solution for treatment of diarrhea in children. Results showed that zinc and Prebiotics limit diarrhea duration in patients.
This is due to synergistic activity between zinc and Prebiotics. As, they stimulate water and electrolyte absorption across gut mucosa and inhibiting the pathogens, respectively. Inhibition of pathogens occur due to five mechanisms which are:
- Acidic metabolic end products (acids) that lower the colonic pH below pathogenic bacterial thresholds.
- Competitive effects due to limitations in numbers of colonization sites.
- Antagonism through inhibitory peptides (produced by lactic acid bacteria).
- Competition for limited nutrients.
- Enhancement of the immune system.
Decrease the Permeability to Toxins
Epithelial cells covering the mucus membrane of GI tract act as protective barrier. These epithelial cells are covered with mucous which secreted by goblet cells for further protection from invasion of toxins.
Inflammation in GI tract can cause disturbance in this barrier. This disturbance can lead to passage of Lipopolysaccharides (LPS) which are endotoxins secreted by pathogenic gram negative bacteria.
Studies prove that short chain fatty acids (SCFAs) as acetate, propionate and butyrate, improve the GI barrier. Also, inulin (10gram per day) proved to prevent the passage of LPS in diabetic patients.
Prebiotics decrease the risk of food allergies
As we mentioned, decrease in both Bifidobacteriareside and lactobacilli are associated with inflammations. Also, they are associated with allergic reactions especially in the first five years of life.
Studies show that addition of FOS and GOS (8 gram per liter in cow milk formula for allergic infants) is beneficial in decreasing eczema in these infants. Also, FOS and GOS in hypo- allergic formulas are beneficial to protect from rhino- conjunctivitis.
Enhance Immune System and Fight Cancer
Metabolites released from the fermentation of Prebiotics have shown to be effective in enhancing our immunity. Acetate shows to have apoptosis effect on tumor cells. Propionate has shown to have anti-inflammatory effect.
Butyrate has shown to be effective in stimulating macrophage, T cells and dendritic cells.
Prebiotics lower high cholesterol levels and Prevent Obesity
Prebiotic foods have shown to decrease LDL Cholesterol and triglycerides. Studies showed that intake of soy-fortified Prebiotic resulted in greater reductions in low-density lipoprotein cholesterol and
Also, studies have proved that short-chain FOS can induce satiety and thus prevent obesity.
Consumption of Prebiotics is very beneficial. However, high doses can cause flatulence and diarrhea.